Let's Talk Sevoflurane
Physical Properties SEVOFLURANE is halogenated with fluorine. SEVOFLURANE’s blood/gas partition coefficient is 0.65 . It's non-pungency & rapid increase in alveolar concentration make SEVOFLURANE an excellent choice for smooth & rapid inhalation inductions in peds & adult patients. In fact, you can achieve inhalation induction w/ 4% to 8% SEVOFLURANE in a 50% mixture of NITROUS OXIDE & O2 within 1 min. It has a low blood solubility thus a rapid decrease in alveolar concentration upon discontinuation & quicker emergence compared w/ ISOFLURANE (although not an earlier discharge from the PACU). SEVOFLURANE’s modest vapor P permits the use of a conventional variable bypass vaporizer. Effects on Organ Systems Cardiovascular SEVOFLURANE mildly ↓ myocardial contractility. SVR & BP decrease slightly less than w/ ISOFLURANE or DESFLURANE. Because SEVOFLURANE causes little if any increase in HR, CO is not maintained as well as with ISOFL...